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KRISHGEN Biosystems
has been a pioneer in this field in India helping
toxicologists by providing them tools required for
understanding xenobiotic metabolism.
Xenobiotic
metabolism is the set of metabolic pathways that
modify the chemical structure of xenobiotics, which
are compounds foreign to an organism's normal
biochemistry, such as drugs and poisons.
Xenobiotic
metabolism is divided into three phases. In phase I,
enzymes such as cytochrome P450 oxidases introduce
reactive or polar groups into xenobiotics. These
modified compounds are then conjugated to polar
compounds in phase II reactions. These reactions are
catalysed by transferase enzymes such as glutathione
S-transferases. Finally, in phase III, the
conjugated xenobiotics may be further processed,
before being recognized by efflux transporters and
pumped out of cells. We provide the recombinant
enzymes for Phase I and Phase II studies.
As market leaders
in India today, we work with the world's leading
players for distributing their products and
providing these tools to Indian toxicologists.
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