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 Xenobiotic Metabolism
 
KRISHGEN Biosystems has been a pioneer in this field in India helping toxicologists by providing them tools required for undertanding xenobiotic metabolism.

Xenobiotic metabolism is the set of metabolic pathways that modify the chemical structure of xenobiotics, which are compounds foreign to an organism's normal biochemistry, such as drugs and poisons.

Xenobiotic metabolism is divided into three phases. In phase I, enzymes such as cytochrome P450 oxidases introduce reactive or polar groups into xenobiotics. These modified compounds are then conjugated to polar compounds in phase II reactions. These reactions are catalysed by transferase enzymes such as glutathione S-transferases. Finally, in phase III, the conjugated xenobiotics may be further processed, before being recognized by efflux transporters and pumped out of cells. We provide the recombinant enzymes for Phase I and Phase II studies.

As market leaders in India today, we work with the world's leading players for distributing their products and providing these tools to Indian toxicologists.

We are proud to be associated and work with -

 
 

Xenotech LLc (part of Sekisui Medical, Japan)

 

 

Cypex Limited, U.K.

 

 

Solvo Biotechnology, Hungary

 

 

Sovicell GmbH, Germany

 

 

 

 

 
 
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