IN VITRO DERMAL IRRITATION TESTING
ADVANTAGES OF IN-VITRO DERMAL AND OCULAR IRRITATION TESTING
Carried out in vitro, the SkinEthic reconstructed Epidermis and In Vitro international Irritection method makes it possible to evaluate the irritant potential of chemical products, without using animal testing.
Compared to in vivo study, the SkinEthic reconstructed epidermis and Irritaction assay that allows use of measurement systems that produces quantitative, reproducible results.
The ECVAM validation of the method has shown its reproducibility within and between laboratories, and demonstrated that it is rapid and economical.
- Superior technical expertise.
- Rapid, reliable and cost effective testing.
- Tests carried out as per specific guidelines.
- Advanced data analysis software, data storage and analysis.
- Well-equipped Laboratory with fully automated sample testing systems.
|Test||Model||Starting Price (per sample)||Turnaround time||Sample quantity required||Nature of Sample|
|Dermal Irritation assay||RHE||Contact us||4 – 5 Weeks||40 mg or 40 ul (for triplicate run)||Solid, liquid, cream, gel etc.|
|Episkin||Contact us||4 – 5 Weeks||50 mg or 50 ul (for triplicate run)|
|Irritection Assay||Contact us||2 weeks||Solid : 2gm||Solid, Liq etc.|
|Liquid: 2 ml|
|Ocular Irritation Assay||Contact us||2 weeks||Solid : 2gm|
|Liquid: 2 ml|
- Extra charges applicable if sample needs additional pretreatment.
- Extra charges applicable for rapid turnaround time.
- Please enquire us for more details.
END POINT (UNDER OECD TG 439):
- The MTT cytotoxicity assay:
- A simple robust test for evaluating cellular viability following application of an irritant/toxic agent. The validated method enables evaluation of the viability of epidermal samples after a set time in contact with the product.
- IL – 1α release (optional with extra charges)
- IL1 alpha measurement in culture media increases the sensibility of the test. Products can thus be classified according to EU and OECD norms.