Fc Protein Receptors
The efficacy of a therapeutic antibody is dependent on the Fab fragment and its binding activity to the target antigen, as well as the Fc fragment and its interaction with key Fc receptors. The binding affinity of the Fc fragment towards FcRn (FCGRT&B2M) helps in understanding the antibody’s half life. The affinity between the Fc fragment and FCGRIIIA (CD16a) influence’s the antibody’s ability to elicit ADCC (antibody dependent cell mediated cytotoxicity). Thus, screening for desired binding affinity to these Fc receptors is an essential component in the development of a therapeutic mAb (monoclonal antibody) and characterization for regulatory submissions.
We offer a comprehensive suite and the most extensive range of recombinant Fc receptor proteins, including their common variants, to help expedite your Mab/biosimilar development.
view FC Receptor Proteins
All FCRN/FCGRT reagents are produced in house and quality controlled, including 53 FCRN/FCGRT Gene, 1 FCRN/FCGRT Lysate, 1 FCRN/FCGRT Protein, 3 FCRN/FCGRT qPCR. All FCRN/FCGRT reagents are ready to use.
Recombinant FCRN/FCGRT proteins are expressed by HEK293 Cells with fusion tags as C-AVI & His.
FCRN/FCGRTcDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each FCRN/FCGRT of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.