Description
Pemetrexed, a novel multitargeted antifolate, works by inhibiting three enzymes used in purine and pyrimidine synthesisthymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT). it is a type of chemotherapy as a treatment for pleural mesothelioma.
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