ATMP / GENE THERAPY

ATMPS/GENE THERAPY

ADVANCE THERAPY MEDICINAL PRODUCTS | CELLULAR AND GENE THERAPY PRODUCTS | REAGENTS

KRISHGEN is a leading global supplier of high quality reagents and tools in the expanding market of cell and gene therapy and regenerative medicine.

The company was founded in 2003 and is headquartered in Mumbai, India. KRISHGEN has more than 15 years of expertise in offering the development and GMP manufacturing of cell and gene therapy products.

As a trusted supplier, KRISHGEN offers a comprehensive product portfolio to ensure a seamless transition from research to commercialization. Included in our product portfolio are recombinant human cytokines, serum-free media and closed cell culture systems. Our products combine a maximum of quality and safety with excellent performance due to state-of- the-art production, stringent in-house quality control and comprehensive documentation. All these factors help to simplify qualification and validation for your market authorization.

Apart from our in-house expertise, we rely on specialized leading companies and institutes across the world to offer you a one-shop solution for your needs. Backed by qualified scientists and researchers with years of experience, we understand you. This helps us give a customized tailor-fit product and service.

Dendritic Cells
DCs represent unique antigen-producing cells capable of sensitizing T cells to antigens. They play a central role in the regulation of innate and adaptive immunity. DC therapy represents a new and promising immunotherapeutic approach for treatment of different types of cancer.

rh Cytokines
Genlisa™ GM-CSF, IL-4, IL-1beta, TNFalpha, IL-6, IL-10, IFNgamma
(GMP/preclinical grade)

Medium
Krishgen™ GMP DC

Cat No Product Particulars Pack Size
rh Cytokines
KRC050 Genlisa™ GM-CSF 500 ug / 1000 ug
KRC086 Genlisa™ IL-4 500 ug / 1000 ug
KRC074 Genlisa™ IL-1beta 500 ug / 1000 ug
KRC410 Genlisa™ TNFalpha 500 ug / 1000 ug
KRC090 Genlisa™ IL-6 500 ug / 1000 ug
KRC101 Genlisa™ IL-10 500 ug / 1000 ug
KRC071 Genlisa™ IFNgamma 500 ug / 1000 ug
Medium
KMM01 Krishgen™ GMP DC 500 ml

Embryonic Stem Cells & Induced Pluripotent Stem Cells
ES and iPS cells can differentiate into all cell types of the human body and have the capacity to self-renew. Potential therapeutic applications include basic research, drug testing and regenerative medicine. ES and iPS cells are in addition used as new cell sources for the generation of DC and T cell therapies.

rh Cytokines
Genlisa™ EGF, FGF-2, Activin A, OSM, HGF, TGF-beta1
(GMP/preclinical grade)

Cat No Product Particulars Pack Size
rh Cytokines
KRC031 Genlisa™ EGF 500 ug / 1000 ug
KRC044 Genlisa™ FGF-2 500 ug / 1000 ug
KRC009 Genlisa™ Activin A 500 ug / 1000 ug
KRC210 Genlisa™ OSM 500 ug / 1000 ug
KRC063 Genlisa™ HGF 500 ug / 1000 ug
KRC401 Genlisa™ TGF-beta1 500 ug / 1000 ug

Hematopoietic Stem and Progenitor Cells
HSCs are widely used for transplantation after high- dose chemotherapy of lymphoma, leukemia and certain immune-deficiency illnesses.

rh Cytokines
Genlisa™ SCF, TPO, Flt-3L, IL-3, IL-6
(GMP/preclinical grade)

Medium
Krishgen™ GMP SCGM

Cat No Product Particulars Pack Size
rh Cytokines
KRC328 Genlisa™ SCF 500 ug / 1000 ug
KRC417 Genlisa™ TPO 500 ug / 1000 ug
KRC047 Genlisa™ Flt-3L 500 ug / 1000 ug
KRC082 Genlisa™ IL-3 500 ug / 1000 ug
KRC090 Genlisa™ IL-6 500 ug / 1000 ug
Medium
KMM02 Krishgen™ GMP SCGM 500 ml

T Cells
T cells play a central role in cell-mediated immunity. T cell immunotherapy for cancer, chronic infection and autoimmunity is a rapidly growing field with very promising results in clinical trials. There are currently four types of therapies: chimeric antigen receptor (CAR), tumor-infiltrating lymphocytes (TILs), regulatory T cells (Treg) and T cell receptor (TCR) engineered T cells.

rh Cytokines
Genlisa™ IL-2, IL-7, IL-10, IL-15, IL-21, TGF-beta1
(GMP/preclinical grade)

Cat No Product Particulars Pack Size
rh Cytokines
KRC078 Genlisa™ IL-2 500 ug / 1000 ug
KRC096 Genlisa™ IL-7 500 ug / 1000 ug
KRC101 Genlisa™ IL-10 500 ug / 1000 ug
KRC118 Genlisa™ IL-15 500 ug / 1000 ug
KRC121 Genlisa™ IL-21 500 ug / 1000 ug
KRC401 Genlisa™ TGF-beta1 500 ug / 1000 ug

Natural Killer Cells
NK cells are a subset of cytotoxic lymphocytes involved in the innate immune system. They play a major role in the host-rejection of both tumor and virally infected cells. Immunotherapy, based on NK cell infusion, is a potential adjuvant treatment for many cancers.

rh Cytokines
Genlisa™ IL-2, IL-15, IL-21
(GMP/preclinical grade)

Medium
Krishgen™ GMP SCGM

Cat No Product Particulars Pack Size
rh Cytokines
KRC078 Genlisa™ IL-2 500 ug / 1000 ug
KRC118 Genlisa™ IL-15 500 ug / 1000 ug
KRC121 Genlisa™ IL-21 500 ug / 1000 ug
Medium
KMM02 Krishgen™ GMP SCGM 500 ml

Mesenchymal Stem Cells
MSCs are multipotent stem cells that can be differentiated into a variety of cell types, including osteoblasts, chondrocytes, myocytes, adipocytes, pancreatic islets cells and neuronal cells. They hold great therapeutic promise in the field of cell-based tissue engineering and regenerative medicine. MSCs are being used for the prevention or treatment of GvHD after allogeneic blood stem cell transplantation. Their immunomodulatory properties are furthermore employed in autoimmune diseases such as diabetes and Crohn’s disease.

rh Cytokines
Genlisa™ EGF, FGF-2, PDGF-BB, TGF-beta1
(GMP/preclinical grade)

Medium
Krishgen™ MSC, preclinical grade

Cells
Krishgen™ hUC-MSC

Coating Material
Krishgen™ Gelatin, preclinical grade

Cat No Product Particulars Pack Size
rh Cytokines
KRC031 Genlisa™ EGF 500 ug / 1000 ug
KRC044 Genlisa™ FGF-2 500 ug / 1000 ug
KRC223 Genlisa™ PDGF-BB 500 ug / 1000 ug
KRC401 Genlisa™ TGF-beta1 500 ug / 1000 ug
Medium
KMM03 Krishgen™ MSC, preclinical grade 500 ml
Cells
KCC01 Krishgen™ hUC-MSC 1 million cells / vial
Coating Material
KCS01 Krishgen™ Gelatin, preclinical grade 1 gm

Chondrocytes
Chondrocytes are the only cell type resident in the cartilage. Chondrocytes are, for example, used for the generation of articular cartilage injuries in the knee (Autologous Chondrocyte Transplantation, ACT).

rh Cytokines
Genlisa™ FGF-2, PDGF-BB
(GMP/preclinical grade)

Coating Material
Krishgen™ Gelatin, preclinical grade

Cat No Product Particulars Pack Size
rh Cytokines
KRC044 Genlisa™ FGF-2 500 ug / 1000 ug
KRC223 Genlisa™ PDGF-BB 500 ug / 1000 ug
Coating Material
KCS01 Krishgen™ Gelatin, preclinical grade 1 gm

(CAR-T) CHIMERIC ANTIGEN RECEPTOR T-CELL THERAPY
(TCR) T-CELL RECEPTOR THERAPY

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