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COVID-19 Antigen Reagents

The ongoing pneumonia outbreak in the city of Wuhan is caused by a newly identified coronavirus 2019-nCoV, named by the World Health Organization on January 12nd, 2020. This new virus belongs to the Betacoronavirus Genus, which also includes SARS CoV (2003) and MERS CoV (2012). The sequence similarity between 2019-nCoV and MERS-CoV is 40%, while that between 2019-nCoV and SARS-CoV is 70%.

What is the Coronaviruses

Coronaviruses are large, enveloped, positive-sense single- stranded RNA viruses. They have the largest genome among all RNA viruses, typically ranging from 27 to 32kb. The molecular weight is usually (5.5-6.1) x 106.

What are the Antigens of Coronavirus?

The genome of coronavirus encodes the spike protein, the envelope protein, the membrane protein, and the nucleocapsid protein.The spike protein is the most important surface protein. The main functions for the Spike protein is summarized below:

(1) The spike protein mediates receptor binding and membrane fusion. (2) The spike protein defines the range of the hosts and specificity of the virus. (3) The spike protein can be transmitted between different hosts through gene recombination or mutation of the receptor binding domain (RBD), leading to a higher mortality rate. (4) The spike protein is the main component to bind with the neutralizing antibody. (5) The spike protein is the key target for vaccine design.

The Structure of Spike Protein.

The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion. It’s been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor.

The Nucleocapsid Protein.

Nucleocapsid is an unit of viral structure, consisting of a capsid with the enclosed nucleic acid; it is generally inside the cytoplasm. The nucleocapsid may correspond to a naked core or be surrounded by a membranous envelope depending on the virus.

The nucleocapsid protein (N-protein) is the most abundant protein in coronavirus. The N-protein is a highly immunogenic phosphoprotein, and well conserved and is often used as a marker in diagnostic assays.

ELISA KITS

KLR130 | GENLISA Rat Anti-SAR-CoV (SDA/RCV) IgG ELISA (Enzyme Immunoassay for the Qualitative determination of IgG Antibodies to Rat Coronavirus (SDA/RCV) in rat sera)


KBVH015-1 | GENLISA Human SARS-CoV IgG ELISA Enzyme Immunoassay for the Quantitative determination of Human Coronavirus IgG in serum and plasma.


KBVH015-2 | GENLISA Human Anti-SARS-CoV-2 (Covid-19) Spike Protein IgG ELISA (Enzyme Immunoassay for the Qualitative determination of IgG Antibodies to SARS-CoV-2 (Covid-19) Spike Protein in respiratory specimens and serum *(under CE registration))


KBVH015-3 | GENLISA Human Anti-SARS-CoV-2 (Covid-19) Nucleocapsid Protein IgG ELISA (Enzyme Immunoassay for the Qualitative determination of IgG Antibodies to SARS-CoV-2 (Covid-19) Nucleocapsid Protein in respiratory specimens and serum *(under CE registration)


KBVH015-4 | GENLISA Human SARS-CoV-2 (Covid-19) Nucleocapsid Protein ELISA (Enzyme Immunoassay for the Quantitative Determination of Antigen Human SARS-CoV-2 (Covid-19) Nucleoprotein in respiratory specimens and serum *(under CE registration))


KBVH015-5 | GENLISA Human SARS-CoV-2 (Covid-19) Qualitative ELISA (Enzyme Immunoassay for the Qualitative Determination of SARS-CoV- 2 (Covid-19) Antigen in respiratory specimens and human serum)


REAL TIME PCR KITS

KBRT010 | GENLISA Human SARS-Cov-2 (Covid-19) Real Time PCR Kit Real Time PCR kit for Estimation of SARS-Cov2 (Covid-19) [as per CDC Atlanta Guidelines] in respiratory specimens and serum.)


RAPID STRIPS/CASSETTES

KBR010 | GENLISA Human Anti-SARS-CoV-2 (Covid-19) IgM Rapid Test (Rapid Immunochromatography for the qualitative determination of Covid-19 (SARS-CoV-2) in serum, plasma and whole blood)


KBR011 | GENLISA Human Anti-SARS-CoV-2 (Covid-19) IgG/IgM Rapid Test (Rapid Immunochromatography for the qualitative determination of IgG/IgM antibodies to Covid-19 (SARS-CoV-2) in serum, plasma and whole blood.)

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