Genome editing technology is now widely used for making gene knockout/knock-in animals and plants as well as genome-modified cell lines. KRISHGEN provides three types of genome-editing protein: wtCas9, eSpCas9(1.1), AsCpf1 that exhibit higher efficiency, specificity and undetectable off -target effect.
Cas9 protein is a purified nuclease from E coli using Cas9 gene of Streptococcus pyogenes. It is a ready-to-use product containing a nuclear localization signal (NLS) for genome editing experiments resulting site-specific cleavage of double stranded DNA
Key Features of the Genome Editing Proteins:
|Product||Cas9 Protein||eSpCas9(1.1)||AsCpf1 Protein|
|Off-target Effect||Low||Not Detectable||Not Detectable|
|Size||50 ug / 500 ug / 1mg||50 ug / 500 ug / 1mg||50 ug / 500 ug / 1mg|
High Activity - Cas9 Protein:
KB-SGR50 | sgRNA (sgRNA mRNA is chemically synthesized and ready-to-use product containing a custom-designed sgRNA for excellent efficiency and specificity. Along with Cas9 protein or eSpCas9 (1.1) protein these ready-to-inject reagents are suitable for producing gene-editing animals via one-cell embryos injection. This product can also be used to directly cut the target sequence in vitro)
KB-CRR20 | crRNA (crRNA is chemically synthesized and ready-to-use product containing a custom-designed sgRNA for excellent efficiency and specificity. Along with AsCpf1 protein (these ready-to-inject reagents are suitable for producing gene-editing animals via one-cell embryos injection. This product can also be used to directly cut the target sequence in vitro)
KB-cas9-50ug/500ug/1mg | wtCas9 Protein (see typical lot release data)
KB-cas901-50ug/500ug/1mg | eSpCas9(1.1) Protein (see typical lot release data)
KB-cpf1-50ug/500ug/1mg | AsCpf1 Protein (see typical lot release data)
Total 11 products.
Dr Jayaraman D. Lead Scientist, leading CRO companyI have been working with a team from KRISHGEN on an assay development and customization before giving us. The project was complicated and needed technical expertise in immunology. I was very pleased with their technical competence and also mastering immunology and delivering a tough project to us on time. Their rigor, punctuality and expertise have been a recipe for the high standards, I would expect for such project from them. Kudos, Krishgen Team!!!
Mr Ramesh Sravanan, VP-Supply ChainThe expertise and command on the logistics chain including the regulatory guidelines from Krishgen is something we admire. As they often indicate, let us do the supplies, and let your team focus on science … is really something the company works on. Delivering consistently, with less than 1% error or delay consistently is the key to their success.
Dr Keith Stevens, visiting Scientist, Norfolk University, UKTo have a company understand science and work with them, is a pleasure. Krishgen not only sells but understands what it sells in terms of the complex cutting edge sceince.
Mellisa Karlowski, Lead Researcher, east coast US CROThe company is good on understanding its customers, is transparent and speaks science. This makes it easier for us to work with them.
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