Cytokine storm, also known as high cytokine disease, is the systemic expression of a healthy and vigorous immune system resulting in the release of more than 150 inflammatory mediators such as TNF-α, IL-1, IL-6, IL-12, IFN-α, IFN-β, IFN-γ, MCP-1, and IL-8.
Both pro-inflammatory cytokines and anti-inflammatory cytokines are elevated in the serum, and the fierce and often lethal interplay of these cytokines is referred to as a "Cytokine Storm".
It is a severe excessive immune response caused by a positive feedback cycle between cytokines and immune cells. The symptoms are high fever, redness, swelling, extreme fatigue and nausea, which can be fatal in some cases. Cytokine storm is an important cause of acute respiratory distress syndrome and multiple organ failure.
Krishgen has available a range of cytokine ELISAs for monitoring cytokine storms in COVID-19 patients.
Our product portfolio caters to a broad spectrum of the Coronavirus proteins to enable diagnostic / vaccine manufacturers, researchers choose the protein of interest.
Dr Jayaraman D. Lead Scientist, leading CRO company
I have been working with a team from KRISHGEN on an assay development and customization before giving us. The project was complicated and needed technical expertise in immunology. I was very pleased with their technical competence and also mastering immunology and delivering a tough project to us on time. Their rigor, punctuality and expertise have been a recipe for the high standards, I would expect for such project from them. Kudos, Krishgen Team!!!
Mr Ramesh Sravanan, VP-Supply Chain
The expertise and command on the logistics chain including the regulatory
guidelines from Krishgen is something we admire. As they often indicate, let us
do the supplies, and let your team focus on science … is really something the
company works on. Delivering consistently, with less than 1% error or delay
consistently is the key to their success.
Dr Keith Stevens, visiting Scientist, Norfolk University, UK
To have a company understand science and work with them, is a pleasure. Krishgen
not only sells but understands what it sells in terms of the complex cutting
Mellisa Karlowski, Lead Researcher, east coast US CRO
The company is good on understanding its customers, is transparent and
speaks science. This makes it easier for us to work with them.